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We investigated how interactions between executive function and the largely overlooked factor of emotion regulation might relate to the incidence of symptoms of psychotic thinking in youth with 22q. We measured neural activity with event\u2010related potentials (ERPs) in variants of an inhibitory function (Go\/No\u2010Go) experimental paradigm that presented affective or non\u2010affective stimuli. The study replicated inhibition impairments in the 22q group that were amplified in the presence of stimuli with negative, more than positive affective salience. Importantly, the anterior N2 conflict monitoring ERP significantly increased when youth with 22q viewed angry and happy facial expressions, unlike the typically developing participants. This suggests that youth with 22q may require greater conflict monitoring resources when controlling their behavior in response to highly salient social signals. This evidence of both behavioral and neurophysiological differences in affectively influenced inhibitory function suggests that frequently anxious youth with 22q may struggle more with cognitive control in emotionally charged social settings, which could influence their risk of developing symptoms of psychosis.<\/jats:p>","DOI":"10.1002\/ajmg.a.61596","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T11:14:01Z","timestamp":1587554041000},"page":"1615-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis\u2010proneness symptoms in youth with chromosome 22q11.2 deletion syndrome"],"prefix":"10.1002","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-1585","authenticated-orcid":false,"given":"Samantha 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