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Using three\u2010dimensional stereo photogrammetric device, 14 craniofacial anthropometric measurements were performed and five indices were calculated in 52 children with Williams syndrome and 208 age and sex matched controls of Han Chinese ethnicity. Except intercanthal width, mouth breadth, morphological face height, nasal height\u2010breadth index, nasal breadth\u2010depth index, morphological ear index, the Williams syndrome group under 3\u2009years old were smaller than the control group in the other 12 variables. Compared with the control group, the Williams syndrome group aged 3\u20135\u2009years old had smaller biocular breadth, nasal length, nasorostral angle, bitragal breadth, ear width, morphological ear index and face depth. The Williams syndrome group aged above 6\u2009years old had smaller biocular breadth, nasal breadth, bitragal breadth, ear width, ear length and face depth than the control group. The craniofacial variability index of the Williams syndrome group was greater than the control group. Greater variation was found among children with Williams syndrome than normal in China, specifically at eye, nose, ear and face shape, which demonstrate the usefulness of three\u2010dimensional stereo photogrammetric analysis in supporting accurate diagnose of the patient with Williams syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.a.61750","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T13:29:29Z","timestamp":1595597369000},"page":"2102-2109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A study on facial features of children with Williams syndrome in China based on three\u2010dimensional anthropometric measurement technology"],"prefix":"10.1002","volume":"182","author":[{"given":"Chai","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Pediatric Health Care, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for 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