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Reduced palpebral fissure length is one of the cardinal facial features of FASD. However, other ocular measurements have not been studied extensively in FASD. Using the Fetal Alcohol Syndrome Epidemiologic Research (FASER) database, we investigated how inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance (OCD) centiles differed between FASD and non\u2010FASD individuals. We compared ocular measurement centiles in children with FASD to non\u2010FASD individuals and observed reductions in all three centiles for ICD, IPD, and OCD. However, when our non\u2010FASD children who had various forms of growth deficiency (microcephaly, short\u2010stature, or underweight) were compared to controls, we did not observe a similar reduction in ocular measurements. This suggests that reductions in ocular measurements are a direct effect of alcohol on ocular development independent of its effect on growth parameters, which is consistent with animal models showing a negative effect of alcohol on developing neural crest cells. Interpupillary distance centile appeared to be the most significantly reduced ocular measure we evaluated, suggesting it may be a useful measure to be considered in the diagnosis of FASD.<\/jats:p>","DOI":"10.1002\/ajmg.a.61759","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T03:43:15Z","timestamp":1594957395000},"page":"2243-2252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ocular measurements in fetal alcohol spectrum disorders"],"prefix":"10.1002","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-3546","authenticated-orcid":false,"given":"Diego A.","family":"Gomez","sequence":"first","affiliation":[{"name":"College of Arts and Sciences Creighton University  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Center on Alcoholism, Substance Abuse, &amp; Addictions University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara G.","family":"Tabachnick","sequence":"additional","affiliation":[{"name":"Department of Psychology California State University  Northridge California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Hasken","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Lyden","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy O.","family":"Kalberg","sequence":"additional","affiliation":[{"name":"Center on Alcoholism, Substance Abuse, &amp; Addictions University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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