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To corroborate and expand these findings, we report on two novel syndromic male patients with 9p13 deletions suffering from a similar form of tremor and compare them with literature data. Despite genomic variability in deletion sizes, all patients displayed homogeneous dysmorphism and clinical manifestations, including very invalidating tremor. Furthermore, we outlined a region of around 2 Mb shared in common by all patients with nearly 70 genes, among which <jats:italic>NPR2<\/jats:italic> might have a role in the phenotype. These data delineate interstitial 9p13 deletion syndrome with tremor as a major feature.<\/jats:p>","DOI":"10.1002\/ajmg.a.61807","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T07:57:32Z","timestamp":1599638252000},"page":"2694-2698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tremor is a major feature of 9p13 deletion syndrome"],"prefix":"10.1002","volume":"182","author":[{"given":"Susana Isabel","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Cytogenetics and Genomics, Faculty of Medicine University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Cinnirella","sequence":"additional","affiliation":[{"name":"Medical Genetics Residency Program Tor Vergata University of Rome and University of L'Aquila  L'Aquila 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