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Individuals with CSS often present with feeding difficulties and failure to thrive during infancy, in addition to a number of variable congenital anomalies. Nutritional interventions are used to support growth in this population, and growth hormone therapy has been reported in a limited number of cases. The purpose of this study was to construct CSS\u2010specific growth charts to better characterize the growth in this population. Anthropometric data were collected from 99 individuals enrolled in the CSS\/BAF pathway international registry via a retrospective chart review. All measurements obtained after the first exposure to growth hormone therapy were excluded from this analysis. Sex\u2010specific centiles (5th, 50th, and 95th) were estimated for height, weight, and head circumference from birth to age 10. Cubic smoothing splines were then fit to the centile estimates and superimposed on normative male and female growth curves for comparison. The CSS patients in this cohort exhibited normal growth parameters at birth. By age 10, the weight and head circumference of the CSS cohort began to approach normal parameters. Stature, however, remained shortened at 10\u2009years of age.<\/jats:p>","DOI":"10.1002\/ajmg.a.61823","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:58:26Z","timestamp":1599065906000},"page":"2253-2262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth charts for individuals with <scp>Coffin\u2010Siris<\/scp> syndrome"],"prefix":"10.1002","volume":"182","author":[{"given":"Emily A.","family":"McCague","sequence":"first","affiliation":[{"name":"Master of Public Health Program Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Department of Clinical Translational Sciences Marshall University  Huntington West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Holt","sequence":"additional","affiliation":[{"name":"Master of Public Health Program Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-0644","authenticated-orcid":false,"given":"Samantha A.","family":"Schrier Vergano","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics and Metabolism Children's Hospital of The King's Daughters  Norfolk Virginia USA"},{"name":"Department of Pediatrics Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32111"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.165"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-017-1757-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25730"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0868"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08911"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320590111"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.068"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31407"},{"issue":"314","key":"e_1_2_8_11_1","first-page":"1","article-title":"CDC growth charts: United States","volume":"8","author":"Kuczmarski R. 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