{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:23Z","timestamp":1792782203205,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Colorado Center for Innovative Design and Analysis","id":[{"id":"https:\/\/ror.org\/00jc20583","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ehlers\u2010Danlos Syndromes (EDS) and related Hypermobility Spectrum Disorders (HSD) are debilitating connective tissue disorders that feature a prominent pain component for which there are limited therapeutic options for pain management. Consequently, many patients try various non\u2010prescribed treatments, including complementary and alternative therapies that have not been well studied in the EDS\/HSD patient population. We surveyed over 500 individuals through the EDS Society who reported having been diagnosed with EDS or HSD to ascertain what complementary and alternative therapies were used and their reported effectiveness in alleviating pain and improving quality of life. Specifically, we focused on the use of traditional Chinese therapies, herbal medications, and marijuana. The most commonly reported therapies, used by 70\u201392% of participants, were non\u2010steroidal anti\u2010inflammatory drugs, acetaminophen, opioids, and physical therapy. Therapies rated by participants as most efficacious were opioids, physical therapy, and marijuana with 10\u201324% of those using these therapies rating them as extremely helpful. Patient\u2010initiated complementary therapy use in EDS\/HSD patients is widespread at 56%. Complementary therapies were largely utilized by EDS\/HSD patients with higher reported pain levels. Providers caring for EDS\/HSD patients should be aware of these data showing broad usage of predominantly non\u2010prescribed therapies and be prepared to consider such usage in working collaboratively with these patients to develop comprehensive treatment plans to manage their chronic pain complications.<\/jats:p>","DOI":"10.1002\/ajmg.a.61837","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T03:22:20Z","timestamp":1600831340000},"page":"2611-2623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Use of complementary therapies for chronic pain management in patients with reported\n                    <scp>Ehlers\u2010Danlos<\/scp>\n                    syndrome or hypermobility spectrum disorders"],"prefix":"10.1002","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-7758","authenticated-orcid":false,"given":"Jessica 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