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So far, only five families have been reported. We now identified a novel, homozygous splice variant in <jats:italic>LAMC3<\/jats:italic> in an individual with an unusual manifestation of cortical malformation. She presented with polymicrogyria in the frontal but not the occipital lobes, with adult\u2010onset seizures and normal psychomotor development and cognition. Additionally, ictal asystole, requiring implantation of a pacemaker, and nonepileptic seizures occurred. This case expands the spectrum of <jats:italic>LAMC3<\/jats:italic>\u2010associated cortical malformation phenotypes to frontal only polymicrogyria and adult\u2010onset of epilepsy.<\/jats:p>","DOI":"10.1002\/ajmg.a.61846","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:00:51Z","timestamp":1600963251000},"page":"2761-2764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A novel splice variant expands the <scp><i>LAMC3<\/i><\/scp>\u2010associated cortical phenotype to frontal only polymicrogyria and adult\u2010onset epilepsy"],"prefix":"10.1002","volume":"182","author":[{"given":"Burkhard S.","family":"Kasper","sequence":"first","affiliation":[{"name":"Epilepsy Center, Department of Neurology University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Kraus","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"R\u00f6sch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian T.","family":"Thiel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-2020","authenticated-orcid":false,"given":"Christiane","family":"Zweier","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002404"},{"key":"e_1_2_8_3_1","volume-title":"Manual zum Regensburger Wortfl\u00fcssigkeits\u2010Test","author":"Aschenbrenner S.","year":"2000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.22826"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.836"},{"key":"e_1_2_8_6_1","volume-title":"Test zum kognitiven Sch\u00e4tzen: TKS. 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