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Individual\/focus group concept elicitation interviews were conducted with parents of children aged 2 to &lt;12\u2009years with achondroplasia and experts. Qualitative analysis of transcripts, based on an adapted grounded theory approach, informed item generation and measure development. Cognitive debriefing (CD) interviews were conducted with parents to confirm relevance and understanding. Thirty\u2010six parents participated in concept elicitation interviews. The analysis identified major physical symptoms\/complications and impacts of achondroplasia, which informed the development of the Achondroplasia Child Experience Measures (ACEMs): ACEM\u2014Symptom and ACEM\u2014Impact. ACEM\u2014Symptom was comprised of eight major symptoms\/complications including pain (58%), ear infections\/fluid in ear (56%), and low stamina\/tiring easily (56%). ACEM\u2014Impact consisted of 31 major impacts in the domains of daily functioning, emotional well\u2010being, social well\u2010being, and need for assistance\/adaptive devices. Impacts on functioning included difficulty reaching objects\/high places (89%) and toileting (67%). Emotional impacts included feeling different (53%) and feeling frustrated\/annoyed (47%). Social impacts included difficulty participating in sports\/physical play (86%) and being treated as younger than age (83%). Following CD interviews with 16 additional parents, validation\u2010ready ACEM measures were generated. The study improves our understanding of the experiences of children with achondroplasia and provides evidence supporting the content validity of the ACEMs. Validated ACEMs may be used to assess potential benefits of future treatments for comorbidities of achondroplasia.<\/jats:p>","DOI":"10.1002\/ajmg.a.61903","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T06:28:12Z","timestamp":1603261692000},"page":"33-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Assessing physical symptoms, daily functioning, and well\u2010being in children with achondroplasia"],"prefix":"10.1002","volume":"185","author":[{"given":"Kathryn M.","family":"Pfeiffer","sequence":"first","affiliation":[{"name":"Health Outcomes Research The Brod Group California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-5838","authenticated-orcid":false,"given":"Meryl","family":"Brod","sequence":"additional","affiliation":[{"name":"Health Outcomes Research The Brod Group California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alden","family":"Smith","sequence":"additional","affiliation":[{"name":"Market Access Ascendis Pharma, Inc. 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