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After experiencing a minor traumatic injury to the abdomen, consisting of falling over a bathroom stool on the way to the restroom with a full bladder, the child developed acute abdominal pain. He was found to have an intraperitoneal bladder rupture that was successfully repaired with management techniques tailored to his known diagnosis of vEDS. While tissue fragility and internal organ rupture occurring with minor trauma are known complications of vEDS, this is the first case in the literature of a bladder rupture in a child with vEDS with a confirmed variant in the <jats:italic>COL3A1<\/jats:italic> gene, to our knowledge. This case broadens the clinical presentation of vEDS, demonstrates that children can have life\u2010threatening organ rupture at a young age, and may alert providers to consider this diagnosis when a child presents with bladder rupture.<\/jats:p>","DOI":"10.1002\/ajmg.a.62004","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T10:14:09Z","timestamp":1607422449000},"page":"841-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intraperitoneal bladder rupture in a young child with vascular <scp>Ehlers\u2010Danlos<\/scp> syndrome"],"prefix":"10.1002","volume":"185","author":[{"given":"Rahul","family":"Nanduri","sequence":"first","affiliation":[{"name":"Cardiovascular Clinical Research Core, Section of Cardiology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jones","sequence":"additional","affiliation":[{"name":"Scott Department of Urology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Miller\u2010Hance","sequence":"additional","affiliation":[{"name":"Section of Pediatric Cardiology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Anesthesiology Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-4276","authenticated-orcid":false,"given":"Andrea M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-0934","authenticated-orcid":false,"given":"Shaine A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Section of Pediatric Cardiology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800560404"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31829c7a59"},{"key":"e_1_2_8_4_1","unstructured":"ByersP.2019.Vascular Ehlers\u2010Danlos syndrome. 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