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SF\u201036 Health Survey scores from adults with achondroplasia were compared to general population scores. Demographics, physical measurements, and psychiatric illness diagnoses were recorded from medical records. The achondroplasia population had lower scores than the general population in all categories. Most people with achondroplasia (56%) had a diagnosed psychiatric illness. Those with a diagnosed psychiatric illness had lower scores in physical functioning, role limitations due to physical and emotional health, and mental health. Pain, energy\/fatigue, and general health scale scores were roughly equivalent (&lt;2 points difference). Social functioning was &gt;15 points higher in individuals with psychiatric illness diagnoses. Adults with achondroplasia report significantly lower physical and mental well\u2010being and had nearly 3\u00d7 the rate of psychiatric illness diagnosis than the general population, highlighting the importance of total care for this population. Healthcare providers must understand the physical and mental comorbidities of achondroplasia, beyond short stature and orthopedic issues, so they can proactively improve QoL across the lifespan for patients and families.<\/jats:p>","DOI":"10.1002\/ajmg.a.62018","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T08:12:42Z","timestamp":1608883962000},"page":"695-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Quality of life in adults with achondroplasia in the United States"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-1820","authenticated-orcid":false,"given":"Elizabeth A.","family":"Yonko","sequence":"first","affiliation":[{"name":"Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Hospital for Special Surgery  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian S.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Hospital for Special Surgery  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Carter","sequence":"additional","affiliation":[{"name":"Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Hospital for Special Surgery  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen L.","family":"Raggio","sequence":"additional","affiliation":[{"name":"Kathryn O. and Alan C. 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