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Here, we present a 31\u2010year\u2010old Chinese woman with MDPL, harboring the recurrent pathogenic variant p.(Ser605del) in <jats:italic>POLD1<\/jats:italic>, illustrating the evolving manifestations of this premature aging disorder from infancy to adulthood.<\/jats:p>","DOI":"10.1002\/ajmg.a.62035","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T16:06:42Z","timestamp":1608826002000},"page":"995-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evolving clinical manifestations of mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome: From infancy to adulthood in a 31\u2010year\u2010old woman"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-6145","authenticated-orcid":false,"given":"Pui Tak","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Health Clinical Genetic Service  Kowloon 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