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Mutations in <jats:italic>PER2<\/jats:italic> are associated with familial advanced sleep\u2010phase syndrome 1 (FASPS1), and recently suggested in delayed sleep phase syndrome and idiopathic hypersomnia. The detection of <jats:italic>PER2<\/jats:italic> variants in individuals with autism spectrum disorder (ASD) and without reported sleep disorders, has suggested a role of circadian\u2010relevant genes in the pathophysiology of ASD. It remains unclear whether these individuals may have, in addition to ASD, an undiagnosed circadian rhythm sleep disorder. The MSSNG database was used to screen whole genome sequencing data of 5,102 individuals with ASD for putative mutations in <jats:italic>PER2<\/jats:italic>. Families identified were invited to complete sleep phenotyping consisting of a structured interview and two standardized sleep questionnaires: the Pittsburgh Sleep Quality Index and the Morningness\u2010Eveningness Questionnaire. From 5,102 individuals with ASD, two nonsense, one frameshift, and one <jats:italic>de novo<\/jats:italic> missense <jats:italic>PER2<\/jats:italic> variants were identified (0.08%). Of these four, none had a diagnosed sleep disorder. Three reported either a history of, or ongoing sleep disturbances, and one had symptoms highly suggestive of FASPS1 (as did a mutation carrier father without ASD). The individual with the missense variant did not report sleep concerns. The ASD and cognitive profiles of these individuals varied in severity and symptoms. The results support a possible role of <jats:italic>PER2<\/jats:italic>\u2010related circadian rhythm disturbances in the dysregulation of sleep overall and sometimes FASPS1. The relationship between dysregulated sleep and the pathophysiology of ASD require further exploration.<\/jats:p>","DOI":"10.1002\/ajmg.a.62086","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T06:26:31Z","timestamp":1611210391000},"page":"1120-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the <scp><i>PER2<\/i><\/scp> circadian rhythm gene"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-7438","authenticated-orcid":false,"given":"Ny","family":"Hoang","sequence":"first","affiliation":[{"name":"Department of Genetic Counselling The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Genetics and Genome Biology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Molecular Genetics University of Toronto  Toronto 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