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The aim of this study was to estimate the frequency and the types of co\u2010occurring anomalies in cases with gastroschisis and omphalocele. This study was performed in a well\u2010described population of 387,067 consecutive births between 1979 and 2007. Hundred\u2010one cases with omphalocele were registered (2.61 per 10,000), 75 (74.3%) had co\u2010occurring anomalies comprising chromosomal anomalies (28 cases, 27.7%, including 18 trisomy 18), non\u2010chromosomal syndromes (16 cases, 15.8%, including 3 cases with Beckwith\u2013Wiedemann syndrome, 2 cases with the OEIS sequence, and one case with the Pentalogy of Cantrell complex), and 31 cases, 30.7% with MCA (multiple congenital anomalies). The most common MCA were musculoskeletal (23.5%), urogenital (20.4%), cardiovascular (15.1%), and central nervous (9.1%). Seventy\u2010one cases of gastroschisis were ascertained (1.83 per 10,000). However, the prevalence increased during the study period. The frequency was highest in the mothers 15\u201319\u2009years old. Sixteen out of the 71 cases with gastroschisis, (22.5%) had co\u2010occurring anomalies including 11 cases of MCA and 5 cases with syndromes. To conclude, the frequency and the types of anomalies co\u2010occurring with omphalocele and gastroschisis are peculiar. Therefore, cases with gastroschisis and omphalocele need to be screened for co\u2010occurring anomalies.<\/jats:p>","DOI":"10.1002\/ajmg.a.62112","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T02:21:03Z","timestamp":1619058063000},"page":"1954-1971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Co\u2010occurring non\u2010omphalocele and non\u2010gastroschisis anomalies among cases with congenital omphalocele and gastroschisis"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-9257","authenticated-orcid":false,"given":"Claude","family":"Stoll","sequence":"first","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, Facult\u00e9 de M\u00e9decine University of Strasbourg  Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Alembik","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, Facult\u00e9 de M\u00e9decine University of Strasbourg  Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Paule","family":"Roth","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, Facult\u00e9 de M\u00e9decine University of Strasbourg  Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211616"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00078-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318412"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00534.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.11.052"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.3.F209"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320580218"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420470109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31577"},{"key":"e_1_2_9_11_1","unstructured":"EUROCAT. 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