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However, some develop cardiovascular symptoms such as arrhythmias, heart failure, and ventricular inflow\/outflow tract obstruction in the neonatal period with early death. Many of these tumors are not candidates for surgical resection and medical management is limited. Treatment with mammalian target of rapamycin (mTOR) inhibitor is currently approved for the management of central nervous tumors and angiomyolipoma in TSC. Two patients with malignant arrhythmias related to nonsurgical multiple rhabdomyomas associated with TSC who were successfully treated with an mTOR inhibitor were described. Everolimus therapy showed significant regression of rhabdomyomas with rapid improvement of arrhythmias and heart failure prior to tumor shrinkage.<\/jats:p>","DOI":"10.1002\/ajmg.a.62120","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T04:09:55Z","timestamp":1613707795000},"page":"1525-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Everolimus for severe arrhythmias in tuberous sclerosis complex related cardiac rhabdomyomas"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-6455","authenticated-orcid":false,"given":"Mar\u00eda P.","family":"Silva\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5881","authenticated-orcid":false,"given":"Jorge L.","family":"Alvarado\u2010Socarras","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia  Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-0939","authenticated-orcid":false,"given":"Javier","family":"Castro\u2010Monsalve","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia  Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-7014","authenticated-orcid":false,"given":"Keyla Milena","family":"Meneses","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia  Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8238-3209","authenticated-orcid":false,"given":"Justo","family":"Santiago","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia  Floridablanca Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-3531","authenticated-orcid":false,"given":"Carlos E.","family":"Prada","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular de Colombia  Floridablanca Colombia"},{"name":"Division of Human Genetics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1800352"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.09.050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1688-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951116000421"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.06.076"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3476"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/apc.APC_79_18"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu056"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"1","article-title":"Ventricular repolarization abnormalities: The electrocardiographic track of cardiac tumoural involvement in an infant with tuberous sclerosis complex. 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