{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:17:00Z","timestamp":1780629420836,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sleep disorders are frequent in tuberous sclerosis complex (TSC) during the developmental age but are not well characterized. Forty\u2010six TSC patients and 46 healthy age\u2010 and sex\u2010matched controls were enrolled. Their parents completed the Sleep Disturbances Scale for Children (SDSC) and the Child Behavior Checklist (CBCL). A total of 17.4% of the TSC patients obtained a total pathologic score at the SDSC versus 4.4% in the control group (<jats:italic>p<\/jats:italic> = 0.024). 45.7% of individuals with TSC reported a pathologic score in at least one of the factors. We found a statistically significant difference between the TSC cohort and healthy controls for most of the CBCL scales scores. A significant relationship was found between the Total SDSC score and the Total CBCL score (R\u2010square = 0.387, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), between the Total SDSC score and the Internalizing and Externalizing areas scores (R\u2010square = 0.291, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 and R\u2010square = 0.350, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, respectively) of the CBCL. Sleep disorders are more frequent in TSC than in the general population and correlate with behavior. The use of SDSC and CBCL is proposed as part of the surveillance of TSC patients in the developmental age.<\/jats:p>","DOI":"10.1002\/ajmg.a.62123","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T05:43:57Z","timestamp":1614663837000},"page":"1421-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sleep and behavior in children and adolescents with tuberous sclerosis complex"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8476-0960","authenticated-orcid":false,"given":"Elena","family":"Zambrelli","sequence":"first","affiliation":[{"name":"Epilepsy Center\u2010Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. Paolo e Carlo San Paolo Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Turner","sequence":"additional","affiliation":[{"name":"Epilepsy Center\u2010Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. Paolo e Carlo San Paolo Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-6548","authenticated-orcid":false,"given":"Angela","family":"Peron","sequence":"additional","affiliation":[{"name":"Epilepsy Center\u2010Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. Paolo e Carlo San Paolo Hospital  Milan Italy"},{"name":"Department of Health Sciences University of Milan  Milan Italy"},{"name":"Human Pathology and Medical Genetics Unit, ASST SS. Paolo e Carlo, San Paolo Hospital  Milan Italy"},{"name":"Department of Pediatrics, Division of Medical Genetics University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Leidi","sequence":"additional","affiliation":[{"name":"Epilepsy Center\u2010Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. Paolo e Carlo San Paolo Hospital  Milan Italy"},{"name":"Department of Health Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"La Briola","sequence":"additional","affiliation":[{"name":"Epilepsy Center\u2010Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. 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