{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:23:55Z","timestamp":1761719035533,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The COVID\u201019 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS\u2010CoV\u20102 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID\u201019 infection. The SARS\u2010CoV\u20102 virus does not appear to cause a more severe metabolic deterioration than is typical.<\/jats:p>","DOI":"10.1002\/ajmg.a.62161","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T06:28:41Z","timestamp":1615271321000},"page":"1854-1857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Management of <scp>COVID<\/scp>\u201019 infection in organic acidemias"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-7470","authenticated-orcid":false,"given":"Shagun","family":"Kaur","sequence":"first","affiliation":[{"name":"Division of Genetic, Genomic, and Metabolic Disorders Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Division of Genetic, Genomic, and Metabolic Disorders Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Stockton","sequence":"additional","affiliation":[{"name":"Division of Genetic, Genomic, and Metabolic Disorders Children's Hospital of Michigan  Detroit Michigan USA"},{"name":"Discipline of Pediatrics Central Michigan University  Mount Pleasant Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"unstructured":"American Academy of Pediatrics. (2020 October 29).Children and COVID\u201019: State Data Report.https:\/\/downloads.aap.org\/AAP\/PDF\/AAP%20and%20CHA%20\u2010%20Children%20and%20COVID\u201019%20State%20Data%20Report%2010.29.20%20FINAL.pdf","key":"e_1_2_7_2_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1186\/s13023-014-0130-8"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.15585\/mmwr.mm6937e4"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1186\/s13023-020-01563-w"},{"unstructured":"Centers for Disease Control and Prevention. (2020).Demographic Trends of COVID\u201019 cases and deaths in the US reported to CDC. U.S. Department of Health & Human Services Centers for Disease Control and Prevention.https:\/\/covid.cdc.gov\/covid-data-tracker\/#demographics","key":"e_1_2_7_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1542\/peds.2020-0702"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1093\/jpids\/pix093"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.62161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.a.62161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.62161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T14:10:37Z","timestamp":1693577437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.62161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ajmg.a.62161"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.62161","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"type":"print","value":"1552-4825"},{"type":"electronic","value":"1552-4833"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}