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There is a markedly increased number of individuals with Amyoplasia who are one of monozygotic (MZ) twins, with the other twin being normal. Thus, it would appear that Amyoplasia is definitely associated with and may be caused by an MZ twinning event. The twin\u2013twin transfusion seen in MZ twins could play an etiologic role in producing Amyoplasia. In this article, Amyoplasia twinning is compared to twinning in other forms of arthrogryposis. The accompanying paper examines various types of MZ twinning (Hall, 2021). Amyoplasia is primarily associated with spontaneous MZ twinning.<\/jats:p>","DOI":"10.1002\/ajmg.a.62172","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T09:49:36Z","timestamp":1616579376000},"page":"1816-1821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>The mystery of monozygotic twinning<\/scp> I: What can Amyoplasia tell us about monozygotic twinning and the possible role of <scp>twin\u2013twin<\/scp> transfusion?"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-491X","authenticated-orcid":false,"given":"Judith G.","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Medical Genetics, British Columbia Children's Hospital University of British Columbia and Children's and Women's Health Centre of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61847"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0206"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009461213139"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90112-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1905165"},{"key":"e_1_2_11_8_1","first-page":"3","article-title":"A retrospective study of pregnancy complications among 828 cases of arthrogryposis","volume":"1","author":"Fahy M.","year":"1990","journal-title":"Genetic Counselling"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.27"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14237-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-383834-6.00168-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36397"},{"key":"e_1_2_11_13_1","article-title":"The mystery of monozygotic twinning ii: What can monozygotic twinning tell us about amyoplasia from a review of the various mechanisms and types of monozygotic twinning?","author":"Hall J. 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