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We present a liveborn male with a birth weight\u2009below the\u2009first percentile associated with placental mosaicism involving eight 2.4\u20133.9 Mb de novo duplications. We found that the duplications likely co\u2010localized to the same cells, were mosaic in the placenta, and impacted maternal and paternal chromosomes. In addition, 27.4\u2009Mb and 240 genes were duplicated in affected cells, including candidate placental genes <jats:italic>KISS1<\/jats:italic> and <jats:italic>REN<\/jats:italic>. We ruled out involvement of homologous recombination\u2010based mechanisms or an altered epigenome in generating the CNVs. This case highlights the diversity of genetic abnormalities in the human placenta and the gaps in our knowledge of how such errors arise.<\/jats:p>","DOI":"10.1002\/ajmg.a.62183","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T09:45:10Z","timestamp":1616406310000},"page":"1908-1912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Confined placental mosaicism involving multiple de novo copy number variants associated with fetal growth restriction: A case report"],"prefix":"10.1002","volume":"185","author":[{"given":"Giulia F.","family":"Del Gobbo","sequence":"first","affiliation":[{"name":"BC Children's Hospital Research Institute  Vancouver Canada"},{"name":"Department of Medical Genetics University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Yuan","sequence":"additional","affiliation":[{"name":"BC 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