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The patient achieved present adaptive and motor skills in his teenage years. He is able to move on the floor in a sitting position. He seems happy and has not shown any behavioral or psychiatric symptoms. New signs not described in the literature before are accelerated growth after puberty and atypical sleeping position with upper body resting on legs.<\/jats:p>","DOI":"10.1002\/ajmg.a.62213","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T13:19:05Z","timestamp":1620134345000},"page":"2164-2167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Natural history of alpha\u2010thalassemia X\u2010linked intellectual disability syndrome: A case report of a 45\u2010year\u2010old man"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-6179","authenticated-orcid":false,"given":"Maria","family":"Arvio","sequence":"first","affiliation":[{"name":"P\u00e4ij\u00e4t\u2010H\u00e4me Joint Municipal Authority, Neurology  Lahti Finland"},{"name":"PEDEGO Oulu University Hospital  Finland"},{"name":"KTO\u2010Southwest Special Care Municipal Authority  Paimio Finland"},{"name":"Department of Child Neurology Turku University, Turku University Central Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"L\u00e4hdetie","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Turku University, Turku University Central Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00641.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.4.539"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.4.679"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32253"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Alpha thalassaemia\u2010mental retardation, X linked","volume":"4","author":"Gibbons R. 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