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Because of a range of clinical presentations and molecular defects involving Chromosome 11p15, many cases will fall within what is now being defined as the Beckwith\u2013Wiedemann spectrum (BWSp). Cushing syndrome (CS) in infants is a rare neuroendocrinological disease associated with hypercortisolism that has rarely been reported in patients with BWS. Here, we describe the first case of a 5\u2010month\u2010old male with CS secondary to paternal uniparental disomy of Chromosome 11p without additional clinical signs or symptoms of BWS. This case continues to expand the phenotypic spectrum of BWSp.<\/jats:p>","DOI":"10.1002\/ajmg.a.62255","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T22:49:00Z","timestamp":1620514140000},"page":"2824-2828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Cushing syndrome: An early sign of an underling cancer predisposition syndrome"],"prefix":"10.1002","volume":"185","author":[{"given":"Bahareh M.","family":"Schweiger","sequence":"first","affiliation":[{"name":"Department of Pediatrics Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaya L.","family":"Esakhan","sequence":"additional","affiliation":[{"name":"Technion\u2010Israel Institute of Technology American Medical School  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-1947","authenticated-orcid":false,"given":"David","family":"Frishberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-2913","authenticated-orcid":false,"given":"Katheryn","family":"Grand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-6480","authenticated-orcid":false,"given":"Ruchira","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-7828","authenticated-orcid":false,"given":"Pedro A.","family":"Sanchez\u2010Lara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-1078"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0790"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446435"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825d538b"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0911-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1061995"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31740"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0734-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.35-9-405"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26432"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311002"},{"issue":"2","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.4103\/2230-8210.104032","article-title":"Pediatric Cushing's disease: Management issues","volume":"16","author":"Savage M. 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