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In this cross\u2010sectional study, Minnesota\u2010based electrocardiographic (ECG) abnormalities, aortic dimensions, routine\u2010 and myocardial strain echocardiographic parameters, and karyotype\u2010cardiac phenotype associations were assessed in girls with TS. In total, 101 girls with TS (0\u201318\u2009years) were included. The prevalence of major ECG abnormalities was 2% (T\u2010wave abnormalities) and 39% had minor ECG abnormalities. Dilatation of the ascending aorta (z\u2010score\u2009&gt;\u20092) was present in 16%, but the prevalence was much lower when using TS\u2010specific z\u2010scores. No left ventricular hypertrophy was detected and the age\u2010matched global longitudinal strain was reduced in only 6% of the patients. Cardiac abnormalities seemed more common in patients with a non\u2010mosaic 45,X karyotype compared with other karyotypes, although no statistically significant association was found. Lowering the frequency of echocardiography and ECG screening might be considered in girls with TS without cardiovascular malformations and\/or risk factors for aortic dissection. Nevertheless, a large prospective study is needed to confirm our results. The appropriate z\u2010score for the assessment of aortic dilatation remains an important knowledge gap. The karyotype was not significantly associated with the presence of cardiac abnormalities, therefore cardiac screening should not depend on karyotype alone.<\/jats:p>","DOI":"10.1002\/ajmg.a.62259","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:00:12Z","timestamp":1620644412000},"page":"2399-2408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cardiac abnormalities in girls with Turner syndrome: <scp>ECG<\/scp> abnormalities, myocardial strain imaging, and karyotype\u2013phenotype associations"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-7241","authenticated-orcid":false,"given":"Iris D.","family":"Noordman","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Amalia Children's Hospital Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zina","family":"Fejzic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Amalia Children's Hospital Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Amalia Children's Hospital Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthonie L.","family":"Duijnhouwer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Weijers","sequence":"additional","affiliation":[{"name":"Medical Imaging, Medical UltraSound Imaging Center Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Kempers","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remy","family":"Merkx","sequence":"additional","affiliation":[{"name":"Medical Imaging, Medical UltraSound Imaging Center Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jani\u00eblle A. 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