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Such inherited chromosomal abnormalities are typically non\u2010mosaic as they are present in the germline. We report the recurrence in two siblings of a mosaicism for a chromosomal rearrangement inherited from their asymptomatic father who carried a balanced t(2;11)(q35;q25) translocation. Both siblings exhibited a similar phenotype including intellectual disability, dysmorphic features, kyphoscoliosis, and cervical spinal stenosis. Karyotyping, fluorescence in situ hybridization and SNP array analysis of blood lymphocytes of both siblings identified two cell lines: one carrying a 2q35q37.3 duplication and a 11q25qter deletion (~90% cells), and one carrying an 11q uniparental isodisomy of maternal origin (~10% cells). We hypothesize that these mosaics were related to a postzygotic rescue mechanism which unexpectedly recurred in both siblings.<\/jats:p>","DOI":"10.1002\/ajmg.a.62361","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T13:01:39Z","timestamp":1622120499000},"page":"3057-3061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recurrence of an early postzygotic rescue of an inherited unbalanced translocation resulting in mosaic segmental uniparental isodisomy of chromosome 11q in siblings"],"prefix":"10.1002","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-0595","authenticated-orcid":false,"given":"Maud","family":"Blanluet","sequence":"first","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and reference center for developmental disorders, FHU G4 G\u00e9nomique, F\u201076000  Rouen 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Meur","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and reference center for developmental disorders, FHU G4 G\u00e9nomique, F\u201076000  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Hannequin","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and reference center for developmental disorders, FHU G4 G\u00e9nomique, F\u201076000  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Mace","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and reference center for developmental disorders, FHU G4 G\u00e9nomique, F\u201076000  Rouen 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