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Eighty\u2010eight children with DS and CHD who underwent surgery between 2009 and 2017 at the tertiary children's hospital in Al\u2010Qassim, Saudi Arabia, were eligible. Information on gender, height, and weight (at surgery, 6 and 12\u2009months), age at surgery, and type of CHD were abstracted from the medical records. Repeated measure analysis of variance (ANOVA) was used for data analysis. The sample's mean age (<jats:italic>SD<\/jats:italic>) was 16.2\u2009months (20.1); 47% were male. Height, weight, and body mass index (BMI) increased significantly at both follow\u2010up points. There was a significant interaction between age at surgery, type of heart disease, and time for all three physical indices (<jats:italic>p<\/jats:italic>\u2010values &lt;0.001). The increase in height, weight, and BMI was significantly greater for children \u22648\u2009months old with acyanotic CHD compared to children &gt;8\u2009months with cyanotic CHD. Overall, the gain in growth was greater for the children with DS who had had surgery at a younger age.<\/jats:p>","DOI":"10.1002\/ajmg.a.62483","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:35:21Z","timestamp":1631126121000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gain in growth after surgical repair of congenital heart disease among children with Down syndrome"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-2839","authenticated-orcid":false,"given":"Nazmus","family":"Saquib","sequence":"first","affiliation":[{"name":"College of Medicine, Sulaiman Al Rajhi University  Al Bukairyah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas Naser","family":"Al Sarraj","sequence":"additional","affiliation":[{"name":"College of Medicine, Sulaiman Al Rajhi University  Al Bukairyah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa Tarek Ziad","family":"Oubaied","sequence":"additional","affiliation":[{"name":"College of Medicine, Sulaiman Al Rajhi University  Al Bukairyah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Mamoun","family":"Rajab","sequence":"additional","affiliation":[{"name":"Calderdale and Huddersfield NHS Foundation Trust, Calderdale Royal Hospital  Halifax UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bana Nasser","family":"Agha","sequence":"additional","affiliation":[{"name":"Prince Sultan Cardiac Center at the Maternity and Children's Hospital  Buraydah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesmin","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology National Heart Foundation  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Almazrou","sequence":"additional","affiliation":[{"name":"College of Medicine, Sulaiman Al Rajhi University  Al Bukairyah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliann","family":"Saquib","sequence":"additional","affiliation":[{"name":"College of Medicine, Sulaiman Al Rajhi University  Al Bukairyah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2013.04.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20130081"},{"issue":"11","key":"e_1_2_11_4_1","first-page":"1211","article-title":"Congenital heart defects in down syndrome patients from western Saudi Arabia","volume":"33","author":"Al\u2010Aama J. 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