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We present the case of a newborn with type C EA\/TEF along with proximal symphalangism found to have a de novo <jats:italic>NOG<\/jats:italic> nonsense mutation. Patients with chromosome 17q deletions including the <jats:italic>NOG<\/jats:italic> gene have previously been reported to have EA\/TEF but mutations in the gene have not been identified in patients with this malformation. This case provides evidence that haploinsufficiency for NOG may be the cause for EA\/TEF in the 17q deletion syndrome and suggests that the clinical spectrum of <jats:italic>NOG<\/jats:italic>\u2010related symphalangism spectrum disorders may include EA\/TEF.<\/jats:p>","DOI":"10.1002\/ajmg.a.62486","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:24:36Z","timestamp":1630567476000},"page":"269-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Esophageal atresia\/tracheoesophageal fistula and proximal symphalangism in a patient with a <scp><i>NOG<\/i><\/scp> nonsense mutation"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-2735","authenticated-orcid":false,"given":"Jonathan","family":"Chooey","sequence":"first","affiliation":[{"name":"Department of Pediatrics Madigan Army Medical Center  Tacoma Washington 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