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In our study, a cohort of 57 patients who underwent heart transplant for dilated cardiomyopathy was screened for variants in <jats:italic>LMNA<\/jats:italic>. We identified a synonymous variant c.936G&gt;A in the last nucleotide of exon 5 of <jats:italic>LMNA<\/jats:italic> in a DCM family. Clinically, the <jats:italic>LMNA<\/jats:italic> variant carriers presented with severe familial DCM, conduction disease, and high creatine\u2010kinase level. The <jats:italic>LMNA<\/jats:italic> c.936G&gt;A variant is novel and has not been reported in current genetic variant databases. Sanger sequencing results showed the presence of <jats:italic>LMNA<\/jats:italic> c.936G&gt;A variant in the genomic DNA but not in the cDNA derived from one family member's heart tissue. Real\u2010time quantitative polymerase chain reaction showed significantly lower <jats:italic>LMNA<\/jats:italic> mRNA levels in the patient's heart compared to the controls, suggesting that the c.936G&gt;A <jats:italic>LMNA<\/jats:italic> variant resulted in reduced mRNA and possibly lower protein expression of <jats:italic>LMNA<\/jats:italic>. These findings expand the understanding on the association between synonymous variant of <jats:italic>LMNA<\/jats:italic> and the molecular pathogenesis in DCM patients.<\/jats:p>","DOI":"10.1002\/ajmg.a.62530","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T01:07:37Z","timestamp":1634519257000},"page":"600-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An <i>LMNA<\/i> synonymous variant associated with severe dilated cardiomyopathy: Case report"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-3630","authenticated-orcid":false,"given":"Shanshan","family":"Gao","sequence":"first","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Mumme\u2010Monheit","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suet Nee","family":"Chen","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine B.","family":"Spector","sequence":"additional","affiliation":[{"name":"DNA Laboratory University of Colorado at Denver and Health Sciences Center  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobromir","family":"Slavov","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco E.","family":"Baralle","sequence":"additional","affiliation":[{"name":"Italian Liver Foundation  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Bristow","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"},{"name":"Adult Medical Genetics Program University of Colorado at Denver and Health Sciences Center  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Cardiovascular Institute, University of Colorado  Aurora Colorado USA"},{"name":"Adult Medical Genetics Program University of Colorado at Denver and Health Sciences Center  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R. 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