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Of the 1434 who completed a questionnaire, 96% would like to receive results that <jats:italic>can guide treatment<\/jats:italic> for their cancer, and preference for receiving this type of result was associated with lower tolerance of uncertainty. Sixty\u2010four percent would like to receive results that <jats:italic>cannot guide treatment<\/jats:italic>, and lower tolerance of uncertainty, self\u2010efficacy, and perceived importance were associated with this preference. Fifty\u2010nine percent would like to receive <jats:italic>variants of unknown significance<\/jats:italic>, which was associated with lower tolerance of uncertainty, higher self\u2010efficacy, and perceived importance. Eighty\u2010six percent wanted to receive <jats:italic>germline results that could inform family risk<\/jats:italic>. This was associated with higher self\u2010efficacy, perceived importance, and perceived susceptibility. Although most patients wanted to receive all types of results, given the differing patient preferences regarding the return of results depending on the utility of the different types of results, it appears critical to safeguard patient understanding of result utility to achieve informed patient choices. This should be accompanied by appropriate consent processes.<\/jats:p>","DOI":"10.1002\/ajmg.a.62563","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T12:36:56Z","timestamp":1636547816000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psychological predictors of advanced cancer patients\u2019 preferences for return of results from comprehensive tumor genomic profiling"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-0784","authenticated-orcid":false,"given":"Bettina","family":"Meiser","sequence":"first","affiliation":[{"name":"Prince of Wales Clinical School University of NSW  Kensington New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis","family":"Butow","sequence":"additional","affiliation":[{"name":"Psycho\u2010Oncology Co\u2010operative Research Group (PoCoG), School of Psychology University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Davies","sequence":"additional","affiliation":[{"name":"Psycho\u2010Oncology Co\u2010operative Research Group (PoCoG), School of Psychology University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Napier","sequence":"additional","affiliation":[{"name":"Cancer Theme, Garvan Institute of Medical Research  Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Schlub","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicci","family":"Bartley","sequence":"additional","affiliation":[{"name":"Psycho\u2010Oncology Co\u2010operative Research Group (PoCoG), School of Psychology University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Juraskova","sequence":"additional","affiliation":[{"name":"Psycho\u2010Oncology Co\u2010operative Research Group (PoCoG), School of Psychology University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy L.","family":"Ballinger","sequence":"additional","affiliation":[{"name":"Cancer Theme, Garvan Institute of Medical Research  Darlinghurst New South Wales Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine University of NSW  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Cancer Theme, Garvan Institute of Medical Research  Darlinghurst New South Wales Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine University of NSW  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Tucker","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of NSW  Kensington New South Wales Australia"},{"name":"Hereditary Cancer Clinic, Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of NSW  Kensington New South Wales Australia"},{"name":"Department of Medical Oncology Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9665-8963","authenticated-orcid":false,"given":"Barbara B.","family":"Biesecker","sequence":"additional","affiliation":[{"name":"RTI International  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan C.","family":"Best","sequence":"additional","affiliation":[{"name":"Psycho\u2010Oncology Co\u2010operative Research Group (PoCoG), School of Psychology University of Sydney  Sydney New South Wales Australia"},{"name":"Institute for Ethics and Society University of Notre Dame Australia  Broadway New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Members of the Psychosocial Issues in Genomics in Oncology (PiGeOn) Project","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"unstructured":"Australian Bureau of Statistics. 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