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Despite extensive research on WS in the last years, the population\u2010specific mutational spectrum still needs to be elucidated. Moreover, there is an evident lack of detailed clinical descriptions accompanied with photographs of affected individuals. Here, we report a consanguineous Lebanese family in whom we identified a pathogenic homozygous nonsense variant c.1111G&gt;T, p.Glu371* in the <jats:italic>WRN<\/jats:italic>. The index individual, at the age of 54\u2009years, was suspected to have WS due to a history of early\u2010onset cataracts, premature hair loss and graying, chronic nonhealing leg ulcers, Achilles' tendon calcifications, type 2 diabetes mellitus, dyslipidemia, hypothyroidism, and premature coronary artery disease. His four sisters, three of which deceased in the fifth decade, had clinical signs suggestive of WS. Moreover, his daughter, aged 23\u2009years, had short stature, hair loss and flat feet. Taken together, we report a detailed clinical course of disease in several affected members of a consanguineous family, which is additionally documented by photographs.<\/jats:p>","DOI":"10.1002\/ajmg.a.62654","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:19:00Z","timestamp":1642411140000},"page":"1630-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Werner syndrome in a Lebanese family"],"prefix":"10.1002","volume":"188","author":[{"given":"Batoul","family":"Jaafar","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Sievers","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-244X","authenticated-orcid":false,"given":"Davor","family":"Lessel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1007\/s00439-010-0832-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/s0047-6374(97)00111-5"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"239","article-title":"Excess of rare cancers in Werner syndrome (adult progeria)","volume":"5","author":"Goto M.","year":"1996","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1002\/humu.20337"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1159\/000056841"},{"volume-title":"GeneReviews\u00ae","year":"1993","author":"Oshima J.","key":"e_1_2_9_8_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1093\/hmg\/5.12.1909"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1038\/gim.2015.30"},{"volume-title":"StatPearls","year":"2021","author":"Sickles C. 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