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Mendelian vascular and connective tissue disorders underlying thoracic aortic disease (TAD), have been reported in ~5% of individuals with SCAD. We therefore hypothesized that patients with TAD are at elevated risk for SCAD. We queried registries enrolling patients with TAD to define the incidence of SCAD. Of 7568 individuals enrolled, 11 (0.15%) were found to have SCAD. Of the sequenced cases (9\/11), pathogenic variants were identified (<jats:italic>N<\/jats:italic>\u00a0=\u20099), including <jats:italic>COL3A1<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u20093), <jats:italic>FBN1<\/jats:italic> (N\u00a0=\u00a02), <jats:italic>TGFBR2<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u20092), <jats:italic>TGFBR1<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u20091), and <jats:italic>PRKG1<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u20091). Individuals with SCAD had an increased frequency of iliac artery dissection (25.0% vs. 5.1%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.047). The prevalence of SCAD among individuals with TAD is low. The identification of pathogenic variants in genes previously described in individuals with SCAD, particularly those underlying vascular Ehlers\u2013Danlos, Marfan syndrome, and Loeys\u2013Dietz syndrome, is consistent with prior reports from clinical SCAD series. Further research is needed to identify specific genetic influences on SCAD risk.<\/jats:p>","DOI":"10.1002\/ajmg.a.62661","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T08:56:19Z","timestamp":1643446579000},"page":"1448-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spontaneous coronary artery dissection is infrequent in individuals with heritable thoracic aortic disease despite partially shared genetic susceptibility"],"prefix":"10.1002","volume":"188","author":[{"given":"Andrea M.","family":"Murad","sequence":"first","affiliation":[{"name":"Division of Genetic Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Hill","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Human Genetics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Human Genetics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ghannam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Lee","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Human Genetics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma L.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Division, Center for Clinical Research Network Coordination RTI International  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute  Hyattsville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Hornsby","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Cardiovascular Health Improvement Project (CHIP) Biorepository  Ann Arbor Michigan 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