{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:14:28Z","timestamp":1784290468555,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral clefts (OCs) are frequently co\u2010occurring with other non\u2010OC congenital anomalies. The types and the prevalence of anomalies co\u2010occurring with OCs vary in the reported studies. The aims of this report were to study the types and the prevalence of the anomalies co\u2010occurring with OCs in a well\u2010defined population. The types and the prevalence of anomalies co\u2010occurring in cases with OCs were ascertained in all terminations of pregnancy, stillbirths, and live births in 387,067 births occurring consecutively during the period 1979\u20132007 in the area covered by our registry of congenital anomalies which is population based, 789 cases of OCs were registered during the study period with a prevalence of 20.4 per 10,000 births, 39.5% of the cases had associated non\u2010OC anomalies. Associated anomalies were more common in cases with cleft palate (52.4%) than in cases with cleft lip and palate (37.3%) and in cases with cleft lip only (16.8%). Chromosomal abnormalities were present in 94 (11.9%) cases including 27 trisomies 13, 15 trisomies 18, 12 22 q11.2 deletion, and 40 other chromosomal abnormalities. Nonchromosomal recognizable conditions were diagnosed in 38 cases (4.8%) including syndromes, associations, spectrums and sequences. Multiple congenital anomalies (MCAs) were present in 180 cases (22.8%). The most frequent MCA were in the musculoskeletal system (16.7%), the central nervous system (15.0%), the urogenital system (13.7%), the cardiovascular system (8.6%), and the digestive system (6.6%). The high prevalence of associated anomalies justifies a thorough screening for other congenital anomalies in cases with OCs.<\/jats:p>","DOI":"10.1002\/ajmg.a.62689","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T11:41:38Z","timestamp":1645184498000},"page":"1700-1715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Co\u2010occurring anomalies in congenital oral clefts"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-9257","authenticated-orcid":false,"given":"Claude","family":"Stoll","sequence":"first","affiliation":[{"name":"Genetique Medicale, Faculte de Medecine Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Alembik","sequence":"additional","affiliation":[{"name":"Genetique Medicale, Faculte de Medecine Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Roth","sequence":"additional","affiliation":[{"name":"Genetique Medicale, Faculte de Medecine Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844317809010478"},{"key":"e_1_2_9_3_1","unstructured":"The Cleft Palate\u2010Craniofacial Journal 2021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38513"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320580218"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-074.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31447"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"issue":"8","key":"e_1_2_9_9_1","first-page":"1021","article-title":"Epidemiologie des fentes labio\u2010palatines: Experience du registre de malformations congenitales d'Alsace entre 1995 et 2006. 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