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This study investigated the prevalence and impact of OI in young women across the hypermobility spectrum. Forty\u2010five women (14\u201330\u2009years, 15 controls, 15\u2009G\u2010HSD, and 15 hEDS) undertook a head\u2010up tilt (HUT) and active stand test. Postural Orthostatic Tachycardia Syndrome (POTS) and Orthostatic Hypotension (OH) were assessed using age\u2010related criteria. Autonomic dysfunction and quality\u2010of\u2010life questionnaires were also completed. The prevalence of POTS was higher in women with G\u2010HSD than hEDS and control groups during HUT (43% vs. 7% and 7%, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but similar between groups during the active stand (47%, 27%, and 13% for G\u2010HSD, hEDS, and control, respectively). No participants had OH. hEDS and G\u2010HSD participants reported more severe orthostatic symptoms and poorer quality of life than controls. Although POTS was observed in hypermobile participants, there is no conclusive evidence that its prevalence differed between groups due to differences between the HUT and active stand assessments. Nevertheless, OI and broader autonomic dysfunction impacted on their quality of life.<\/jats:p>","DOI":"10.1002\/ajmg.a.62705","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T07:40:27Z","timestamp":1646034027000},"page":"1761-1776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The prevalence and impact of orthostatic intolerance in young women across the hypermobility spectrum"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-9127","authenticated-orcid":false,"given":"Karen C.","family":"Peebles","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Tan","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of 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