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A subset of patients with a milder presentation has been described with short stature and developmental delay but minimal immune and hematologic features. Some patients with LAD II benefit from oral fucose therapy, though this has not been previously studied in patients with milder disease. In this study, we describe two new patients from separate families with the milder variant of LAD II and review the published literature on this rare disorder. We demonstrate improvement in speech and cognition, CD15 expression, and core fucosylation of serum glycoproteins after 27\u2009months of oral fucose supplementation in one patient. These patients further support the stratification of this disorder into distinct subtypes, a classical severe and an attenuated variant, and provide preliminary evidence of benefit of fucose therapy in the latter group.<\/jats:p>","DOI":"10.1002\/ajmg.a.62737","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T13:18:43Z","timestamp":1648300723000},"page":"2005-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Defining the mild variant of leukocyte adhesion deficiency type <scp>II<\/scp> (<scp>SLC35C1<\/scp>\u2010congenital disorder of glycosylation) and response to <scp>l<\/scp>\u2010fucose therapy: Insights from two new families and review of the literature"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-5817","authenticated-orcid":false,"given":"Shawn","family":"Tahata","sequence":"first","affiliation":[{"name":"Department of 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