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The data were collected from three regional sites in the NIAAA\u2010funded Collaboration on FASD Prevalence (CoFASP). Dysmorphology examinations were performed by a team of expert clinical geneticists, and FASD diagnoses were assigned according to the Revised Institute of Medicine Guidelines, which include assessments of growth, dysmorphology, neurobehavior, and maternal risk interviews. We present detailed data on 32 physical traits, minor anomalies, and a summary dysmorphology score for children within each of the four diagnostic categories in the continuum of FASD. There were few differences in the frequency of FASD diagnoses by race or Hispanic ethnicity. Children with FASD were born to mothers who reported using alcohol, tobacco (28.3%), and other drugs (14.2%) during pregnancy. Controlling for tobacco and other drug use, risk analysis indicated that women with a drinking pattern of 3 drinks per drinking day prior to pregnancy were 10 times more likely (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, OR\u00a0=\u00a09.92, 95% CI: 4.6\u201321.5) to bear a child with FASD than those who reported abstinence prior to pregnancy.<\/jats:p>","DOI":"10.1002\/ajmg.a.62738","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T11:43:41Z","timestamp":1648727021000},"page":"2019-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characteristic physical traits of first\u2010grade children in the United States with fetal alcohol spectrum disorders (<scp>FASD<\/scp>) and associated alcohol and drug exposures"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-8701","authenticated-orcid":false,"given":"Philip A.","family":"May","sequence":"first","affiliation":[{"name":"Nutrition Research Institute The University of North Carolina at Chapel Hill  Kannapolis North Carolina USA"},{"name":"Center on Alcohol, Substance Abuse and Addictions The University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Hasken","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute The University of North Carolina at Chapel Hill  Kannapolis North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie A.","family":"Manning","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Pediatrics Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luther K.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics State University of New York  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-9989","authenticated-orcid":false,"given":"Omar","family":"Abdul\u2010Rahman","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Munroe\u2010Meyer Institute, University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret P.","family":"Adam","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamison","family":"Jewett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Avera Health  Sioux Falls South Dakota USA"},{"name":"Department of Pediatrics University of South Dakota Sanford School of Medicine  Sioux Falls South Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy O.","family":"Kalberg","sequence":"additional","affiliation":[{"name":"Center on Alcohol, Substance Abuse and Addictions The University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Buckley","sequence":"additional","affiliation":[{"name":"Center on Alcohol, Substance Abuse and Addictions The University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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