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The clinical features typically include microcephaly, multiple cutaneous capillary malformations, seizures, neurologic impairment, and global developmental delay. Currently, there is little published information about the natural history and long\u2010term outcomes for individuals with MIC\u2010CAP. In this report, we provide follow up on two previously published patients and describe four new patients. The included patients highlight increased variability in the clinical spectrum and provide novel information regarding medical complications and recurrent variants.<\/jats:p>","DOI":"10.1002\/ajmg.a.62936","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T10:54:26Z","timestamp":1660388066000},"page":"3350-3357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Further clinical delineation of microcephaly\u2010capillary malformation syndrome"],"prefix":"10.1002","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-0842","authenticated-orcid":false,"given":"Julianne K.","family":"Postma","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-8175","authenticated-orcid":false,"given":"Jessica L.","family":"Zambonin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebtissal","family":"Khouj","sequence":"additional","affiliation":[{"name":"Department of Translational Genomics Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suad","family":"Alyamani","sequence":"additional","affiliation":[{"name":"Neuroscience Centre, King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-1078","authenticated-orcid":false,"suffix":"Jr","given":"John M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Medical Genetics, Department of Pediatrics Cedars\u2010Sinai Medical Center, David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-341X","authenticated-orcid":false,"given":"Fowzan S.","family":"Alkuraya","sequence":"additional","affiliation":[{"name":"Department of Translational Genomics Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Kundell","sequence":"additional","affiliation":[{"name":"Thousand Oaks Pediatrics  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-3731","authenticated-orcid":false,"given":"Melissa T.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33841"},{"key":"e_1_2_10_3_1","volume-title":"GeneReviews\u00ae","author":"Carter M. 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