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A comprehensive, retrospective medical history survey was distributed to parents of children with confirmed CFC in collaboration with CFC International, Inc. Data were collected on CFC gene variant, maternal characteristics, pregnancy course, delivery, and neonatal outcomes with the support of medical records. We identified 43 individuals with pathogenic variants in <jats:italic>BRAF<\/jats:italic> (81%), <jats:italic>MEK1<\/jats:italic> (14%), or <jats:italic>MEK2<\/jats:italic> (5%) genes. The median age was 8.5\u2009years. Hyperemesis gravidarum, gestational diabetes, gestational hypertension, and preeclampsia occurred in 5\/43 (12%), 4\/43 (9%), 3\/43 (7%), and 3\/43 (7%) of pregnancies, respectively. Second and third trimester ultrasound abnormalities included polyhydramnios, macrocephaly, macrosomia, and renal and cardiac abnormalities. Delivery occurred via spontaneous vaginal, operative vaginal, or cesarean delivery in 15\/42 (36%), 7\/42 (16%), and 20\/42 (48%), respectively. Median gestational age at delivery was 37\u2009weeks and median birth weight was 3501 grams. Germline pathogenic vaiants had mutiple congenital consequences including polyhydramnios, renal and cardiac abnormalities, macrosomia, and macrocephaly on second and third trimester ultrasound. Elevated rates of operative delivery and neonatal complications were also noted. Understanding and defining a prenatal phenotype may improve prenatal prognostic counseling and outcomes.<\/jats:p>","DOI":"10.1002\/ajmg.a.63020","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T12:14:17Z","timestamp":1667045657000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Obstetrical and neonatal outcomes of cardio\u2010facio\u2010cutaneous syndrome: Prenatal consequences of Ras\/<scp>MAPK<\/scp> dysregulation"],"prefix":"10.1002","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-4029","authenticated-orcid":false,"given":"Angie C.","family":"Jelin","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore Maryland United States"},{"name":"Department of Genetic Medicine Johns Hopkins University School of Medicine  Baltimore Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Mahle","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan H.","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Legacy Medical Group  Portland Oregon United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa N.","family":"Sparks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences University of California San Francisco  San Francisco California United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-7228","authenticated-orcid":false,"given":"Katherine A.","family":"Rauen","sequence":"additional","affiliation":[{"name":"Division of Genomic Medicine, Department of Pediatrics, MIND Institute University of California Davis  Davis California United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35292"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.028"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5076"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.06.035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002456"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000325"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v9i0.1642"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0b013e3182836bb7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36429"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e32833ff29d"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060952"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36737"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1749"},{"key":"e_1_2_9_16_1","volume-title":"Medical genetics: Principles and practice","author":"Nora J. 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E. & Rauen K. A. (2010). Mutational and Functional Analysis in Human Ras\/MAP Kinase Genetic Syndromes. 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