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It is characterized by the formation of multiple benign growing osteochondromas (exostoses) that most commonly affect the long bones; however, it may also occur throughout the body. Although many of these lesions are clinically asymptomatic, some can lead to chronic pain and skeletal deformities and interfere with adjacent neurovascular structures. Here, we report two unrelated probands that presented with a clinical and molecular diagnosis of HME with venous malformation, a clinical feature not previously reported in individuals with HME.<\/jats:p>","DOI":"10.1002\/ajmg.a.63158","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T08:10:28Z","timestamp":1677917428000},"page":"1570-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Venous malformation may be a feature of EXT1\u2010related hereditary multiple exostoses: A report of two unrelated probands"],"prefix":"10.1002","volume":"191","author":[{"given":"Daniah","family":"Albokhari","sequence":"first","affiliation":[{"name":"McKusick\u2010Nathans Department of Genetic Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Pediatrics Taibah University, College of Medicine  Madinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology, The Russell H. 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