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Herein, we compare CMR in young adults with DS, aged 18\u201335\u2009years, to a similar population\u2010based sample from the 2001\u20132018 National Health and Nutrition Examination Survey (NHANES). The group with DS had higher NonHDL\u2010C (mean DS 131.9\u2009mg\/dL; NHANES 126.1 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), lower HDL\u2010C (DS 47.5\u2009mg\/dL; NHANES 52.2 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), higher LDL\u2010C (DS 109.3\u2009mg\/dL; NHANES 105.4 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), higher triglycerides (DS 102.9\u2009mg\/dL; NHANES 86.9 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but lower fasting glucose (DS 85.8\u2009mg\/dL; NHANES 95.2 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), lower HOMA\u2010IR (DS 2.17; NHANES 2.24 <jats:italic>p<\/jats:italic>\u2009=\u20090.0006), lower systolic (DS 109.7\u2009mmHg; NHANES 114.6 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and lower diastolic (DS 60.9\u2009mmHg; NHANES 67.8 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) blood pressures. There was relationship of higher HDL\u2010C, triglycerides, glucose, systolic, and diastolic blood pressure with increasing BMI in the NHANES cohort which was dampened in the group with DS. These results indicate that more information is needed to guide clinicians in screening for CMR in individuals with DS.<\/jats:p>","DOI":"10.1002\/ajmg.a.63197","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T16:24:12Z","timestamp":1680279852000},"page":"1758-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cardiometabolic risk in young adults with <scp>Down<\/scp> syndrome"],"prefix":"10.1002","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-8660","authenticated-orcid":false,"given":"Jacquelyn","family":"Manfredo","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-3730","authenticated-orcid":false,"given":"George","family":"Capone","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Yanek","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McCarter","sequence":"additional","affiliation":[{"name":"Children's National Medical Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette","family":"Zemel","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela N.","family":"Magge","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12868"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-0482"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38512"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.17294\/2330-0698.1824"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01111.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.127"},{"key":"e_1_2_11_9_1","unstructured":"Division of the National Health and Nutrition Examination Surveys. 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