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The objective of this study was to evaluate if adverse childhood experiences (ACEs) were more prevalent in children with DSRD than those with DS alone. A survey\u2010based, cohort\u2010based study was performed. Caregivers of individuals with DSRD with onset of symptoms between age 10 and 30\u2009years and DS alone were administered the ACEs questionnaire via an online REDCap survey. A total of 159 responses were collected after excluding incomplete surveys and those not meeting criteria for DSRD. Individuals with DSRD were not more likely to experience ACEs (<jats:italic>p<\/jats:italic>\u2009=\u20090.18, 95% confidence interval [CI]: 0.43\u20131.17). In those with ACEs prior to the onset of symptoms, the median time prior was 7\u2009months (interquartile range: 5\u201310). Individuals with DSRD were more likely to report three or more ACEs (52, 33%) compared to those with DS alone (39, 22%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02, 95% CI: 1.08\u20132.87). Exposure to ACEs were not predictive of response to particular therapeutic interventions although those with multiple ACEs 3\u2009months prior to the onset of symptoms was associated with lower response rates to benzodiazepines and immunotherapy (<jats:italic>p\u2009=<\/jats:italic>\u20090.02, 95% CI: \u22123.64\u2013\u22121.13). This study provides preliminary data that individuals with DSRD experience ACEs at a similar rate to individuals with only DS alone, although three or more ACEs, often preceding the onset of symptoms, was more prevalent in individuals with DSRD.<\/jats:p>","DOI":"10.1002\/ajmg.a.63199","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T09:31:13Z","timestamp":1680687073000},"page":"1769-1782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adverse childhood experiences and the development of <scp>Down<\/scp> syndrome regression disorder"],"prefix":"10.1002","volume":"191","author":[{"given":"Sarah","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Neurology Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Patel","sequence":"additional","affiliation":[{"name":"Department 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