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This study explored the perspectives of geneticists and intensivists on optimal collaboration and division of roles when implementing rGS in neonatal and pediatric intensive care units (ICUs). We conducted an explanatory mixed methods study involving a survey embedded within an interview with 13 genetics and intensive care providers. Interviews were recorded, transcribed, and coded. Geneticists endorsed higher confidence in performing a physical exam and interpreting\/communicating positive results. Intensivists endorsed highest confidence in determining whether genetic testing was appropriate, communicating negative results, and consenting. Major qualitative themes that emerged were: (1) concerns with both \u201cgenetics\u2010led\u201d and \u201cintensivist\u2010led\u201d models with workflows and sustainability (2) shift the role of determining rGS eligibility to ICU medical professionals, (3) continued role of geneticists to assess phenotype, and (4) include genetic counselors (GCs) and neonatal nurse practitioners to enhance workflow and care. All geneticists supported shifting decisions regarding eligibility for rGS to the ICU team to minimize time cost for the genetics workforce. Exploring models of geneticist\u2010led phenotyping, intensivist\u2010led phenotyping for some indications, and\/or inclusion of a dedicated inpatient GC may help offset the time burden of consenting and other tasks associated with\u00a0rGS.<\/jats:p>","DOI":"10.1002\/ajmg.a.63318","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T13:20:29Z","timestamp":1686835229000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring collaboration models between geneticists and intensivists for implementing rapid genome sequencing in critical care settings"],"prefix":"10.1002","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-8598","authenticated-orcid":false,"given":"Kristen P.","family":"Fishler","sequence":"first","affiliation":[{"name":"Munroe\u2010Meyer Institute for Genetics &amp; Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah S.","family":"Steber","sequence":"additional","affiliation":[{"name":"Munroe\u2010Meyer Institute for Genetics &amp; Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Division of Neonatology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Shope","sequence":"additional","affiliation":[{"name":"College of Allied Health Professions University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24303"},{"key":"e_1_2_9_3_1","unstructured":"ATLAS.ti Scientific Software Development GmbH. 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