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While progress has been made to understand the spectrum of these physical health implications, the impact of OI on psychosocial well\u2010being, as well as protective factors that buffer against adverse psychosocial outcomes, remain understudied. This present study relies on a qualitative approach to assess patient perspectives on both protective and adverse psychosocial factors specific to OI in 15 adults with varying disease status. Semi\u2010structured interviews were conducted, subsequently coded, and themes extracted. Themes concerning psychosocial burdens (i.e., negative affective and behavioral impacts of disease status) and protective factors were identified from cooperatively\u2010coded transcripts (two coders per transcript). Participants reported experiencing an increase in negative affect and disease\u2010related distress after fracturing a bone and during recovery. Fear and concern specific to the uncertainty of future bone fractures and negative self\u2010image was common. In contrast to these negative impacts, participants additionally described positive orientations toward their disease and attributed positive traits to their lived experience with a chronic disease. While limited due to small sample size and lack of ethno\u2010racial diversity, findings highlight a need for continued research on the relationship between OI disease status and psychosocial outcomes, as well as the development of psychological interventions designed for OI populations. Findings have relevant clinical applications for healthcare providers working with those diagnosed with OI.<\/jats:p>","DOI":"10.1002\/ajmg.a.63323","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T08:09:49Z","timestamp":1686816589000},"page":"2267-2275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A qualitative exploration of patient perspectives on psychosocial burdens and positive factors in adults with osteogenesis imperfecta"],"prefix":"10.1002","volume":"191","author":[{"given":"W. 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