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Recently revised diagnostic criteria include the addition of genetic testing to confirm a pathogenic variant, as well as to detect the presence of mosaicism. Therefore, the use and interpretation of both germline and tumor\u2010based testing have increasing importance in the diagnostic approach, treatment decisions, and risk stratification of these conditions. This focused review discusses approaches to genetic testing of NF\u2010 and SWN\u2010related tumor types, which are somewhat rare and perhaps lesser known to non\u2010specialized clinicians. These include gastrointestinal stromal tumors, breast cancer, plexiform neurofibromas with or without transformation to malignant peripheral nerve sheath tumors, gliomas, and schwannomas, and emphasizes the need for inclusion of genetic providers in patient care and appropriate pre\u2010 and post\u2010test education, genetic counseling, and focused evaluation by a medical geneticist or other healthcare provider familiar with clinical manifestations of these disorders.<\/jats:p>","DOI":"10.1002\/ajmg.a.63346","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T06:26:47Z","timestamp":1690180007000},"page":"2467-2481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neurofibromatosis\u2010 and schwannomatosis\u2010associated tumors: Approaches to genetic testing and counseling considerations"],"prefix":"10.1002","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-5072","authenticated-orcid":false,"given":"Allison","family":"Goetsch Weisman","sequence":"first","affiliation":[{"name":"Division of Genetics, Genomics and Metabolism Ann &amp; Robert H. 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