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Low birth weight, growth restriction with feeding difficulties, stature insufficiency, and microcephaly are frequently reported. This study aims to create specific growth charts for individuals with DYRK1A Syndrome and identify parameters for size prognosis. Growth parameters were obtained for 92 individuals with DYRK1A Syndrome (49 males vs. 43 females). The data were obtained from pediatric records, parent reporting, and scientific literature. Growth charts for height, weight, body mass index (BMI), and occipitofrontal circumference (OFC) were generated using generalized additive models through R package <jats:italic>gamlss<\/jats:italic>. The growth curves include height, weight, and OFC measurements for patients aged 0\u20135\u2009years. In accordance with the literature, the charts show that individuals are more likely to present intrauterine growth restriction with low birth weight and microcephaly. The growth is then characterized by severe microcephaly, low weight, and short stature. This study proposes growth charts for widespread use in the management of patients with DYRK1A syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.a.63412","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T06:39:15Z","timestamp":1695451155000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Growth charts in <scp>DYRK1A<\/scp> syndrome"],"prefix":"10.1002","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6660-0688","authenticated-orcid":false,"given":"Pierre\u2010Louis","family":"Lanvin","sequence":"first","affiliation":[{"name":"Service de g\u00e9n\u00e9tique m\u00e9dicale CHU de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Goronflot","sequence":"additional","affiliation":[{"name":"P\u00f4le Hospitalo\u2010Universitaire 11: Sant\u00e9 Publique, Clinique des donn\u00e9es CHU Nantes, Nantes 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