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Variants in <jats:italic>MYLK<\/jats:italic> are primarily known to predispose to TAAD, but a growing body of evidence points toward <jats:italic>MYLK<\/jats:italic> also playing an essential role in the regulation of SMC contraction outside the aorta. In this case report, we present a patient with co\u2010occurrence of persistent ductus arteriosus (PDA) and thoracic aortic dissection. Genetic analyses revealed a novel splice acceptor variant (c.3986\u20101G\u2009&gt;\u2009A) in <jats:italic>MYLK<\/jats:italic>, which segregated with disease in the family. RNA\u2010analyses on fibroblasts showed that the variant induced skipping of exon 24, which resulted in an in\u2010frame deletion of 101 amino acids. These findings suggest that <jats:italic>MYLK<\/jats:italic>\u2010associated disease could include a broader phenotypic spectrum than isolated TAAD, including PDA and obstructive pulmonary disease. Genetic analyses could be considered in families with TAAD and PDA or obstructive pulmonary disease.<\/jats:p>","DOI":"10.1002\/ajmg.a.63458","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:55:34Z","timestamp":1699019734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aortic dissection in a young male with persistent ductus arteriosus and a novel variant in <scp><i>MYLK<\/i><\/scp>"],"prefix":"10.1002","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5428-0739","authenticated-orcid":false,"given":"Maria Bejerholm","family":"Boelman","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-2653","authenticated-orcid":false,"given":"Thomas van 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