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Although many patients experience anxiety and depression, there is little research on psychosocial interventions in this population. The present study examined the effects of a mind\u2013body intervention on depression and anxiety in adults with NF. This is a secondary analysis of the Relaxation Response Resiliency Program for NF (3RP\u2010NF), an 8\u2010week virtual group intervention that teaches mind\u2013body skills (e.g., relaxation, mindfulness) to improve quality of life. Participants were randomized to 3RP\u2010NF or the Health Enhancement Program for NF (HEP\u2010NF) consisting of health informational sessions and discussion. We evaluated depression (PHQ\u20109) and anxiety (GAD\u20107) at posttreatment, 6\u2009months, and 12 months. Both groups improved in depression and anxiety between baseline and posttest, 6 months, and 12 months. The 3RP\u2010NF group showed greater improvements in depression scores from baseline to 6\u2009months compared with HEP\u2010NF and with lower rates of clinically significant depressive symptoms. There were no between\u2010group differences for anxiety. Both interventions reduced distress and anxiety symptoms for individuals with NF. The 3RP\u2010NF group may be better at sustaining these improvements. Given the rare nature of NF, group connection may facilitate reduced distress.<\/jats:p>","DOI":"10.1002\/ajmg.a.63543","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:10:50Z","timestamp":1707297050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of a virtual mind\u2013body program on symptoms of depression and anxiety among international <scp>English<\/scp>\u2010speaking adults with neurofibromatosis"],"prefix":"10.1002","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-1819","authenticated-orcid":false,"given":"Katherine","family":"McDermott","sequence":"first","affiliation":[{"name":"Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafar","family":"Bakhshaie","sequence":"additional","affiliation":[{"name":"Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Brewer","sequence":"additional","affiliation":[{"name":"Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-6488","authenticated-orcid":false,"given":"Ana\u2010Maria","family":"Vranceanu","sequence":"additional","affiliation":[{"name":"Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146167297234003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062817"},{"issue":"9","key":"e_1_2_11_4_1","first-page":"62","article-title":"Dialectical behavior therapy: Current indications and unique elements","volume":"3","author":"Chapman A. 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