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Of 346 participants, 242 (69.9%) had NG\u2010tubes, 17 (4.9%) had G\u2010tubes, and 87 (25.1%) had both NG\u2010 and G\u2010tubes. Primary indication for placement was \u201cfeeding difficulties and\/or poor weight gain\u201d for both NG\u2010 (90.2%) and G\u2010tubes (71.2%), while \u201caspiration\/breathing difficulties\u201d was the procedural indication for 6.4% of NG\u2010tubes and 23.1% of G\u2010tubes. NG\u2010tubes were generally removed by age 6\u2009months (NG Only: 82.9%; NG\/G: 98.8%), while G\u2010tubes were often removed by age 2\u2009years (G Only: 85.7%; NG\/G: 70.5%). The severe complication rate from G\u2010tubes was 31.7% and from NG\u2010tubes was 1.2%. Overall, caregivers indicated the presence of an NG\u2010 or G\u2010tube had a positive effect on quality of life. Feeding difficulties in PWS are largely managed by NG\u2010tube alone. The severe complication rate from G\u2010tubes was about 25 times higher than from NG\u2010tubes; yet, G\u2010tube placement rates have generally increased. G\u2010tube placement puts individuals with PWS at risk for anesthesia and surgery\u2010related complications and should be considered judiciously by a multidisciplinary team.<\/jats:p>","DOI":"10.1002\/ajmg.a.63546","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T05:31:06Z","timestamp":1706851866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feeding tube use and complications in <scp>Prader\u2010Willi<\/scp> syndrome: Data from the <scp>Global Prader\u2010Willi Syndrome Registry<\/scp>"],"prefix":"10.1002","volume":"194","author":[{"given":"Sani M.","family":"Roy","sequence":"first","affiliation":[{"name":"Cook Children's Medical Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Rafferty","sequence":"additional","affiliation":[{"name":"Cook Children's Medical Center  Fort Worth Texas 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