{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:24:57Z","timestamp":1765423497153,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age and gender specific growth charts for Indian children with Down syndrome (DS) based on longitudinal data have not been published. To establish percentile growth charts for DS children inhabiting northwestern parts of India, body weight and length\/height of 1125 (Male: 752, Female: 373) children with DS aged &lt;1\u2009month to 10\u2009years, enrolled from the \u201cGenetics Clinic\u201d were measured at half yearly age intervals in the \u201cGrowth Clinic\u201d of the Institute from August 1994 to November 2018. A total of 2089 observations were made on these children using standardized anthropometric techniques and instruments following a prospective mixed\u2010longitudinal growth research design. Using the LMS method, age and sex\u2010specific percentile growth charts (&lt;1\u2009month to 10\u2009years) for weight, and length\/ height were generated. Unpaired <jats:italic>t<\/jats:italic>\u2010test was used to compare mean growth attainments of study children with those of DS patients representing other population groups as well as their normal Multicentre Growth Reference Study (MGRS and Indian Academy of Pediatrics (IAP) counterparts. The 50th percentile growth curves for both weight and length\/height of Indian children with DS demonstrated a regular increase. As compared to their normal MGRS and Indian (IAP) counterparts, the children with DS had lower weight and height attainments. The boys and girls with Down syndrome showed short stature (height\u2009&lt;\u20093rd centile) from the age of 1\u2009year till 10\u2009years and also became underweight beyond 5\u2009years. As compared to their normal counterparts, children with Down syndrome exhibited compromised auxological attainments. The use of growth charts presented herein may be used to compare and monitor growth and nutritional status of Indian children with Down syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.a.63571","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T13:31:12Z","timestamp":1708608672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Growth charts for weight and height of Indian children with Down syndrome"],"prefix":"10.1002","volume":"194","author":[{"given":"Anil Kumar","family":"Bhalla","sequence":"first","affiliation":[{"name":"Child Growth &amp; Anthropology Unit, Department of Pediatrics Postgraduate Institute of Medical Education &amp; Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-0584","authenticated-orcid":false,"given":"Harvinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Child Growth &amp; Anthropology Unit, Department of Pediatrics Postgraduate Institute of Medical Education &amp; Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Child Growth &amp; Anthropology Unit, Department of Pediatrics Postgraduate Institute of Medical Education &amp; Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7375-9892","authenticated-orcid":false,"given":"Inusha","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Genetics &amp; Metabolic Unit, Department of Pediatrics Postgraduate Institute of Medical Education &amp; Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20130081"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36337"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckl103"},{"key":"e_1_2_9_5_1","first-page":"2","article-title":"Growth chart of Indian girls with down syndrome from birth to three years\u2014A pilot study","volume":"4","author":"Chandrasekhar P.","year":"2018","journal-title":"Journal of Down Syndrome and Chromosomal Abnormalities"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20184272"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole T. 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