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While most PCG patients exhibit epiphora, photophobia, and buphthalmos with corneal opacity, variability in phenotypic manifestations is not uncommon. Prompt diagnosis and treatment of PCG affected individuals becomes relevant to preserve visual function throughout their lives. Most PCG cases are sporadic or autosomal recessive; however, an incompletely dominant autosomal dominant form arising from mutations in the <jats:italic>TEK<\/jats:italic> gene has recently been demonstrated. Here, we describe the clinical and mutational features of a cohort of Mexican patients with <jats:italic>TEK<\/jats:italic>\u2010related PCG. Our results support the involvement of the <jats:italic>TEK<\/jats:italic> gene as an important cause of the disease in our ethnic group and expand the mutational spectrum causing PCG by reporting 10 novel disease\u2010causing variants.<\/jats:p>","DOI":"10.1002\/ajmg.a.63716","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T09:59:01Z","timestamp":1717754341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>TEK<\/i> gene\u2010related primary congenital glaucoma: Phenotypic features and mutational spectrum in a <scp>Mexican<\/scp> cohort of 10 unrelated families"],"prefix":"10.1002","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-6041","authenticated-orcid":false,"given":"Oscar Francisco","family":"Chacon\u2010Camacho","sequence":"first","affiliation":[{"name":"Department of Genetics Institute of Ophthalmology \u201cConde de Valenciana\u201d  Mexico 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