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Here, we analyze register\u2010based associations between NF1 and hospital visits related to oral infections. The Finnish NF1 cohort encompasses all individuals with verified NF1 who have visited the Finnish central and university hospitals in 1987\u20132011. The Finnish Care Register for Health Care allowed the follow\u2010up of 1349 individuals with NF1, their 1894 siblings without NF1, and 13,870 matched controls for diagnoses related to oral infections in 1998\u20132014. We observed clearly increased hazards for hospital visits associated with dental caries (ICD\u201010 K02; NF1 vs. controls, hazard ratio [HR] 4.42, 95% CI 3.23\u20136.04), diseases of pulp and periapical tissues (K04; HR 3.85, 95% CI 2.68\u20135.54), and gingivitis and periodontal diseases (K05; HR 3.63, 95% CI 2.37\u20135.56). In contrast, hospital visits related to diseases of salivary glands (K11), and stomatitis and related lesions (K12) did not show significantly increased hazard in NF1 compared with the controls or the non\u2010NF1 siblings. In conclusion, the findings suggest that hospital visits related to oral infections are relatively common among individuals with NF1. The results highlight the need for early detection, proactive prevention, and timely treatment of oral infections in individuals with NF1.<\/jats:p>","DOI":"10.1002\/ajmg.a.63887","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:08:07Z","timestamp":1727183287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hospital Visits Associated With Oral Infections in Patients With Neurofibromatosis Type 1: A Register\u2010Based Analysis"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-8099","authenticated-orcid":false,"given":"Vivian","family":"Reinhold","sequence":"first","affiliation":[{"name":"Cancer Research Unit, Institute of Biomedicine University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-2980","authenticated-orcid":false,"given":"Roope A.","family":"Kallionp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Cancer Research Unit, Institute of Biomedicine University of Turku  Turku Finland"},{"name":"FICAN West Cancer Centre University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Valtanen","sequence":"additional","affiliation":[{"name":"Cancer Research Unit, Institute of Biomedicine University of Turku  Turku Finland"},{"name":"Department of Public Health and Welfare, Population Health Unit Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Department of Mathematics and Statistics University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Auranen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Turku  Turku Finland"},{"name":"Department of Clinical Medicine University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-5698","authenticated-orcid":false,"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Institute of Dentistry University of Turku  Turku Finland"},{"name":"Department of Pathology Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-1430","authenticated-orcid":false,"given":"Sirkku","family":"Peltonen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology University of Turku  Turku Finland"},{"name":"Department of Dermatology Turku University Hospital  Turku Finland"},{"name":"Department of Dermatology and Venereology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Dermatology and Allergology University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-4167","authenticated-orcid":false,"given":"Juha","family":"Peltonen","sequence":"additional","affiliation":[{"name":"Cancer Research Unit, Institute of Biomedicine University of Turku  Turku Finland"},{"name":"FICAN West Cancer Centre University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"256","article-title":"Oral Findings in 50 Children With Neurofibromatosis Type 1. 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