{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:19:34Z","timestamp":1780373974783,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Many studies have investigated the neuropsychological profile of individuals with sex chromosome trisomies (SCTs) and have identified some fragilities in language development within a wide individual variability. However, only a few studies have focused on children in the second year of life (12\u201324\u2009months), a crucial stage for neurodevelopment. The present study aimed to identify and describe neurodevelopmental patterns in young children with SCTs. Seventy children with SCTs, ranging in age from 14 to 29\u2009months, were administered the Griffiths Mental Development Scales, and their different neurodevelopmental profiles were identified using cluster analysis. Two\u2010step cluster analysis highlighted two profiles of children equally distributed between groups. The two clusters showed a similar pattern but different levels of functioning, with children in Cluster 1 showing a lower performance in all the areas considered than children in Cluster 2. However, in both clusters, all the mean scores were in the normative range, with a significant gap in the linguistic area. Identifying the subgroups of young children with SCTs at higher risk can contribute to developing early monitoring protocols and targeted therapy approaches.<\/jats:p>","DOI":"10.1002\/ajmg.a.63895","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:18:55Z","timestamp":1728285535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurodevelopment in Young Children With Sex Chromosome Trisomies Diagnosed Before Birth: A Cluster Analysis Study"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2207-0179","authenticated-orcid":false,"given":"Laura","family":"Zampini","sequence":"first","affiliation":[{"name":"Department of Psychology University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Lorini","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zanchi","sequence":"additional","affiliation":[{"name":"Department of Psychology Catholic University of the Sacred Heart  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Scionti","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Silibello","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dall'Ara","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Francesca","family":"Ajmone","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Monti","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonella","family":"Costantino","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Giovanna","family":"Vizziello","sequence":"additional","affiliation":[{"name":"Child and Adolescent Neuropsychiatric Unit Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"issue":"15","key":"e_1_2_11_2_1","first-page":"S222","article-title":"The Effectiveness of Motor Activity on Psychomotor Development in School\u2010Aged Children","author":"Abate M.","year":"2020","journal-title":"Journal of Human Sport and Exercise"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O"},{"key":"e_1_2_11_4_1","volume-title":"SPSS TwoStep Cluster\u2014A First Evaluation (Vols 2004\u20132)","author":"Bacher J.","year":"2004"},{"key":"e_1_2_11_5_1","volume-title":"GMDS\u2010R: Griffiths Mental Development Scales, Revised: 0\u20132 Anni","author":"Battaglia F. 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