{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:13:48Z","timestamp":1782339228419,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32MH112485"],"award-info":[{"award-number":["T32MH112485"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002889","name":"Foundation for Prader-Willi Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prader\u2013Willi syndrome (PWS) is a genetic disorder associated with baseline respiratory impairment caused by multiple contributing etiologies. While this may be expected to increase the risk of severe COVID\u201019 infections in PWS patients, survey studies have suggested paradoxically low disease severity. To better characterize the course of COVID\u201019 infection in patients with PWS, this study analyses the outcomes of hospitalizations for COVID\u201019 among patients with and without PWS. The National Inpatient Sample, an all\u2010payors administrative claims database of hospitalizations in the United States, was queried for patients with a coded diagnosis COVID\u201019 in 2020 and 2021. Hospitalizations for patients with PWS compared to those for patients without PWS using Augmented Inverse Propensity Weighting (AIPW). There were 295 (95% CI: 228\u2013362) COVID\u201019 hospitalizations for individuals with PWS and 4,112,400 (95% CI: 4,051,497\u20134,173,303) for individuals without PWS. PWS patients had a median age of 33\u2009years compared to 63 for those without PWS. Individuals with PWS had higher baseline rates of obesity (47.5% vs. 28.4%). AIPW models show that PWS diagnosis is associated with increased hospital length of stay by 7.43\u2009days, hospital charges by $80,126, and the odds of mechanical ventilation and in\u2010hospital death (odds ratios of 1.79 and 1.67, respectively). PWS patients hospitalized with COVID\u201019 experienced longer hospital stays, higher charges, and increased risk of mechanical ventilation and death. These results suggest that PWS should be considered a risk factor for severe COVID\u201019, warranting continued protective measures and vaccination efforts. Further research is needed to validate coding for PWS and assess the impact of evolving COVID\u201019 variants and population immunity on this vulnerable population.<\/jats:p>","DOI":"10.1002\/ajmg.a.63980","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T06:14:45Z","timestamp":1736576085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inpatient Hospitalizations for\n                    <scp>COVID<\/scp>\n                    \u201019 Among Patients With Prader\u2013Willi Syndrome: A National Inpatient Sample Analysis"],"prefix":"10.1002","volume":"197","author":[{"given":"James","family":"Luccarelli","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts 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