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Currently, there is a lack of reports in the literature on adult\u2010onset cases. This case report describes a 51\u2010year\u2010old male with adult\u2010onset HSH, presenting with limb weakness, muscle spasms, and electrolyte imbalances, including severe hypomagnesemia (0.28\u2009mmol\/L). Genetic testing revealed a novel heterozygous variant in the <jats:italic>TRPM6<\/jats:italic> gene (c.4914del, p.E1638Dfs*8), classified as likely pathogenic. The patient's symptoms significantly improved following magnesium supplementation, and his electrolyte levels gradually normalized. This case highlights the importance of considering HSH in patients with unexplained hypomagnesemia and emphasizes the role of genetic testing in confirming the diagnosis. The findings also suggest that magnesium supplementation can effectively alleviate symptoms and improve the quality of life in patients with adult\u2010onset HSH. Early recognition and treatment are crucial to prevent potential complications, such as neurological damage.<\/jats:p>","DOI":"10.1002\/ajmg.a.63982","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:23:56Z","timestamp":1737368636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adult\u2010Onset Hypomagnesemia With Secondary Hypocalcemia Caused by a Novel Variant in <scp><i>TRPM6<\/i><\/scp> Gene: A Case Report"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5357-9390","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Jinwan Hospital of Traditional Chinese and Western Medicine  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The 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